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Uploaded on Nov 13, 2013
Table of Contents: 00:09 Lecture 2.9: First Passage and Narrow Escape Time 01:22 Outline 01:39 MFPT and NET 04:38 Example: NET in 2D 08:20 Example: NET in 2D 08:45 Conclusions 10:22 Summary of lectures 2.2-2.9 10:35 Settling time defines the fundamental limits of detection (Lectures 2.2-2.9) 11:49 Broad range of nanobiosensors 12:40 Settling time: Problem definition 13:51 Strategy: Solution of the Diffusion-capture problem by Transient diffusion capacitance 16:59 A fundamental relationship of biosensor 17:27 Density: Average vs. first arrival time 20:58 A 'Mendeleev table' for biosensors 21:16 Biomimetic Strategies to beat diffusion (1) 23:18 Biomimetic Strategies to beat diffusion (2) 24:11 Strategies to beat diffusion (3) 25:26 Response time for various geometries 26:09 Summary: Lectures 2.2-2.9
This video is part of the nanoHUB-U course "Principles of Electronic Nanobiosensors".
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.