Pathogenicity-Associated Loci in K. pneumoniae




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Published on Jul 23, 2018

Klebsiella pneumoniae is a common cause of infections in the health care setting. This work supports a paradigm for K. pneumoniae pathogenesis where the accessory genome, composed of genes present in some but not all isolates, influences whether a strain causes infection or asymptomatic colonization, after accounting for patient-level factors. Identification of patients at high risk of infection could allow interventions to prevent or rapidly treat K. pneumoniae infections.

DOI: https://doi.org/10.1128/mSystems.0001...

Title: Identification of Pathogenicity-Associated Loci in Klebsiella pneumoniae from Hospitalized Patients

Authors: Rebekah M. Martin (https://orcid.org/0000-0001-9729-0283), Jie Cao, Weisheng Wu, Lili Zhao, David M. Manthei, Ali Pirani, Evan Snitkin, Preeti N. Malani, Krishna Rao (https://orcid.org/0000-0002-9213-7850), Michael A. Bachman (https://orcid.org/0000-0003-2507-6987)

Editor: John F. Rawls

Published in mSystems® on 26 June 2018

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