 This study aimed to assess the effects of the COVID-19 pandemic on the mental health of college students at a large public university in the United States. The results showed that 71% of the 195 students surveyed experience increased stress and anxiety due to the pandemic. Multiple stressors were identified, including fear, and worry about their own health and loved ones, difficulty concentrating, disrupted sleeping patterns, decreased social interactions, and increased concerns on academic performance. To cope with stress and anxiety, participants sought support from others and adopted either negative or positive coping mechanisms. The study highlights the urgent need to develop interventions and preventive strategies to address the mental health of college students during the pandemic. This article was authored by Sun, Changwon, Hegde, Sudeep, Smith, Alec, and others.