 We developed a novel multifunctional microneedle patch, BY plus EGF at MN, consisting of a platilastriate apollosaccharide, BSP, base loaded with epidermal growth factor, EGF. This patch has the ability to rapidly induce hemostasis and subsequently promote wound healing. We tested this patch in a rat hepatic hemorrhage wound model and found it to be effective at reducing bleeding time and increasing neovascularization, fibroblast density, and collagen deposition. This article was authored by Jie Yang, Sao Cheng Wang, Dan Wu, and others.