 A blood-brain barrier disruption for treatment of neurological disease is a major opportunity for numerous conditions afflicting patients. So for example, Parkinson's disease, Alzheimer's disease, brain cancer, these are all diseases where currently treatments are limited by the blood-brain barrier. So if we can open the blood-brain barrier and not only open it but open it in a controlled safe way that's reversible, meaning it's not open permanently, and also open it in a specific targeted location so it's not affecting the entire brain or areas that are not affected by the disease that we're interested in treating. That's a huge opportunity to improve therapeutics and not only to improve therapeutic delivery to that area but it may allow us to limit the dose necessary to give an effective treatment in order to deliver an effective treatment.