 Prostate cancer, PC, represents the most diagnosed and second most lethal cancer in men worldwide. NGF released by cancer cells can be a driver of tumor neurogenesis and nerves infiltrated in TME release neurotransmitters which might stimulate the growth and sustainment of tumor cells. Understanding the molecular basis of this dialogue might expand the arsenal of therapeutic strategies against this widespread disease. This article was authored by Marzia Di Donotto, Pia Giovanelli, Antimo Migliogio and others.