 In October 2020, the observed epidemiology of SARS-CoV-2 in sub-Saharan Africa was found to be markedly different from that in Europe and the U.S., with much lower reported incidents. Population-based studies are necessary to accurately estimate the true cumulative incidents of SARS-CoV-2 to inform public health interventions. This study estimated SARS-CoV-2 in four selected states in Nigeria, finding that 25.2%, 9.3%, 23.3%, and 18% of people had been exposed to the virus in Enugu, GOM, Lagos, and Nazarawa, respectively. Additionally, the study found no significant association between malaria infection and SARS-CoV-2 prevalence. The study also found that the number of reported COVID-19 cases in the four states was only 0.2% of the total population, indicating that the majority of the population remained susceptible to COVID-19 infection. This article was authored by Rosemary A. Audu, Kristen A. Stafford, Laura Steinhardt, and others. We are article.tv. Links in the description below.