 So, we human look all different. As you can see from here, many different people and including my small group of students who look different, behave differently and they are susceptible to different diseases, mainly due to this 0.1% difference in DNA sequence which is of 3 billion base pairs. We have been working on this using this different diversity of DNA sequences and we are surprised by a famous actress, Angelina Jolie, receiving preventive surgery of her breast based on the identification of BRCA1 mutation in her genome. And that surprised us but actually tells us that the importance of this genome-based diagnostics. You are looking at an eye which lost the eye vision because of the genetic disease called abelino-conial dystopia. If one of your parents have this genetic mutation, you will not be blind, however if you receive LASCHIC, you will become blind in two or three years. So diagnostics early is very important. It can be done very easily by swapping some inner cells from your mouse and then you do the PCL amplification of the DNA region and then you hybridize it with pre-pattern thing. Using this technology, we tested more than 440,000 patients who tried to receive LASCHIC, saved 413 people from becoming blind. Also you can use it for testing other genetic diseases such as Wilson's disease which is caused by accumulation of heavy metal ions and you lose the functions of your brain and liver. So that needs to be identified early in the stage so that the child can be treated with proper medicine. You can apply this diagnostic technology for the identification of exact pathogenic micro-organism so that you can administer the right antibiotics without causing antibiotic resistance problems which is becoming more and more significant and also dangerous. Now this can be done in more nano-tech based way. For example, you can make a nano-patterned chip which uses technology called LSPR and then you can use eptoma immobilized on the chip which is specifically captured only the specifically designed pathogenic micro-organisms. Now you get the very simple way of testing it. We eat vegetables fruits every day and you probably did it today too. Sometimes these are contaminated with toxic agri-chemicals which is not good. Can we test it? Well yes, you can do it by using nano-technology. You can make a very inexpensive disposable chip which is immobilized enzyme that can detect such toxic agri-chemicals. Not only diagnostics is the application of marrying nano-tech and biotech. You can produce something. Based on nano-tech, for example, you can identify beautiful metal nanoparticles that can be synthesized by various micro-organisms which is of course engineered to accommodate such heavy metal ions and make something useful as shown in this slide. So you can incubate cells with diverse portfolio of metal ions. You can make quantum dots. You can make metal magnets. You can make some nanoparticles which have never been synthesized by chemists but micro-organisms are capable of doing it. Now you can have various applications but you want to mass-produce it to make money. How you do that? Well, you're looking at cells which are grown in a bioreactor. You're looking at the highest cell density cultivation which contains about 400 billion cells per milliliter of growth which is probably equivalent to filling this room with 500 people and make them live happily for 200 years. You can use high productivity system to produce something such as this one. That is muscle-glue protein which can be used as a water-resistant super adhesive. Now you can clone this gene into E. coli and based on nano-tech you know the structure you want to have. You can have system that allows production of the strongest natural fiber around. That is spider silk. That is as strong as Kevlar which is the strongest manmade fiber. You have bulletproof vest applications, parachute ropes, you can have biomedical applications so actually applications are endless. Now to make this if you look at the DNA sequence and also amino acid sequence in the protein it is very nasty so you cannot allow cells to produce it. Now you can metabolically engineer cells to over-produce this and eventually you will be able to produce enough amount using high cell density culture and then you spin them out to get it actually delivered. So marrying nano-technology and biotechnology not only give you very robust, simple, inexpensive accurate diagnostics but also production of very useful highly functional materials from sustainable resources. Thank you very much.