 Our research suggests that LAIs could potentially replace SMC as a seasonal malaria prevention tool. In order to achieve this, LAIs must have a longer duration of action than SMC, which requires a more thorough understanding of the protective efficacy decay of LAIs. Additionally, LAIs must also have a low cost and be easy to administer, while still maintaining a high level of effectiveness. This article was authored by Lydia Bergert, Teresa Ryker, Monica Golembinu, and others.