 This rapid systematic review identified two clinical studies with available data with limited methodological quality that evaluated the effects of hydroxychloroquine for COVID-19 infection. Based on the findings of these two studies, the efficacy and safety of hydroxychloroquine and chloroquine in patients with COVID-19 is still uncertain, very low evidence certainty, and its routine use for this situation should not be recommended until the results of ongoing studies could provide a proper assessment of their effects.