 Hello everyone welcome back to another session in dentistry and today's topic in oral surgeries anti platelet ricks so they are affecting the platelet aggregation or clot formation So they are also known as anti aggregate anti-aggregant because it is against the aggregation of platelets So these are members of a class pharmaceuticals which decrease the platelet aggregation and inhibits thrombus formation and They are effective in arterial circulation. So it basically prevents the thrombus formation prevent thrombus that is a clot So basically the Clot formation is a fundamental thing of blood coagulation so that Mechanism will be prevented when we use anti platelet ricks So we may have conditions where we are not supposed to have a clot Formation in our blood. So in order to maintain that state we use to consume anti platelet ricks So what is the mechanism of action? So these tricks they have the ability to suppress the production of prostaglandins and thromboxin It's due to its reversible inactivation of the cyclooxygenase enzymes So cyclooxygenase enzymes Will be Inactivated irreversibly. Okay. So these enzymes so that is the cyclooxygenase enzymes are required for prostaglandins and thromboxin synthesis So it is basically to suppress the production of prostaglandin and thromboxin By inactivating this particular enzyme that is a function of anti platelet ricks So these are happy with one or more the ricks which decreases the ability of blood clot To form by interfering with the platelet activation process That is primary hemo stasis So anti platelet ricks can Reversibly or irreversibly inhibit process involved in platelet activation Resulting in decreased tendency to that platelet to adhere to one another and damaged blood vessel endothelium Now let's move on to the classification So in classification First one we have a reversible cyclooxygenase inhibitors So we learned that it inhibiting the cyclooxygenase enzyme Which is involved in the prostaglandin and thromboxin production So this is like irreversible cyclooxygenase inhibitors that is the most common one is aspirin Then trifluosal Trifluosal Which is known as Tiscrin So Brand name that is the first one is the most common aspirin and trifluosal Then we have the ADP receptor inhibitors. That is adenosine diphosphate receptor inhibitors The most common one is clopidocryl Then we have presugral prsugrl Then ticlopidine ticlo Pidin That is the adp receptor inhibitors Now we have protease activated receptor 1 antagonist. Okay, the protease activated receptor It is a PAR1 antagonist. That is vorapaxar VORA PAR Varapaxar Then we have The glycoprotein Inhibitor which is given only through IV intravenously They are adziximab adziximab adziximab It is adci ximab And tirofiban So these are tirofiban So these are glycoprotein inhibitors And One more category we have that is thromboxane inhibitors So the thromboxane inhibitors are terutrobin that is T-E-R-U-T-R-O-B-A-N terutrobin Okay, so these are the commonly used anti platelet drugs So categories are cyclooxygenase inhibitors adp receptor inhibitors Protease activated receptor antagonist glycoprotein inhibitors thromboxane inhibitors And the indications are primary and secondary prevention of cardiovascular disease Then acute ischemic events Myocardial ischemia Cerebral ischemia Atrial fibrillation and trainer that is a chest pain and peripheral artery disease And it can also be used after angioplasty and stent placement That is a very commonly used that is most commonly aspirin is used And after the heart bypass or any valve replacement because the clot formation is very much Bad for this stent and valve because if there is any clot formation The complications will rise for that person who underwent the surgery And also it can be used to prevent the formation of blood clots in people with atrial fibrillation atrial fibrillation So the main contraindications of anti platelet drugs are people who are having risk of bleeding that is active peptic ulcer disease Or people with uncontrolled hypertension Or people with hypersensitivity and allergy and also people with asthma So what are the side effects of these anti platelet tricks the most common is the nausea vomiting stomach upset stomach pain diarrhea the rashes itching swelling of face and hands fever chills and sore throats So that is about anti platelet tricks. So we learned the mechanism Then the various classification its indications contraindications are side effects So it is a commonly asked short not for oral surgery exam. Hope you understood this small concept unit right about the mechanism classification Indication contraindication And lastly the side effects I'll come up with a new topic in oral surgery. Thank you