 Cuproptosis is a type of programmed cell death caused by copper overload, which leads to the formation of lipid aggregates and the loss of iron sulfur clusters from proteins. It has been suggested to be involved in various human diseases, including cancer. Recent research has focused on developing strategies to induce cuproptosis for cancer treatment, such as using small molecules or nanomaterials. This review summarizes the mechanisms of cuproptosis and discusses the potential applications of cuproptosis-inducing agents in cancer therapies. This article was authored by Chang Wei Yi and Chin Rui Fu.