 The study examined the structure of amyloid plaques in the brains of mice with the arctic mutation, which is associated with early onset Alzheimer's disease. They found that the plaques were composed of a lattice-like structure made up of a fibrils, as well as other structures, such as extracellular vesicles, extracellular droplets, and extracellular multilamala bodies. Additionally, they discovered a new type of fibrillar structure, consisting of thin proto-fibril-like rods and branched fibrils. This study provides insight into the structure of amyloid plaques in the brain, and may help to better understand how the structure contributes to the development of AD. This article was authored by Connie Leisner, Martin Wilkinson, Ailee Burgess, and others.