 Alginate is a natural polysaccharide that has been used extensively in biomedicine due to its excellent biocompatibility and biodegradability. It can be processed into three-dimensional scaffolds such as hydrogels, microspheres, microcapsules, sponges, foams and fibers, making it suitable for drug delivery and tissue engineering applications. Alginate-based biomaterials can also be modified by chemical and physical reactions to achieve desired properties, such as tuned degradation rates, mechanical strength, gelation properties and cell affinities. Recent advancements in the use of Alginate and its derivatives in biomedical applications include wound healing, cartilage repair, bone regeneration and drug delivery. These applications have potential in tissue regeneration and could lead to improved treatments for patients. This article was authored by Changin Sun and Huaping Tan.