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Love To Catalyze/Choppin' Tags

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Published on May 2, 2013

This is a video on how enzymes and restriction enzymes work...

"LOVE TO CATALYZE/CHOPPIN' TAGS" LYRICS

CHORUS
Just gonna float, looking for a substrate
if I find it then I will accelerate
As long as it's the right shape and size
I'll help it react because I love to catalyze
I love to catalyze

VERSE
Life's impossible without me.
Won't go quick enough without an enzyme
I'm a protein that find substrates. And I'm
helping them traaaaansform into prod-ucts - in time.
As long as their size is right for my active site
(pause).... Wait some milliseconds. You'll see.
It's like a lock and key, I change but don't get changed. Still me.
...Which means that I can get recycled so I can keep
speed-ing up reactions unless I get de (natured)
What happened!?.... We're changing temp... There goes my shape!
I'm just a glob, can't do my job, so I'm feeling lame
My conformation's strange. I'm no longer in my range.
Back at body temperature things were going great
I can no longer work these substrates - I'm so ashamed
Oh snap- is that the whole point of homeo-stay(sis)?
Stay in the right zone - don't go so high or low again
I guess you don't know your own strength.

CHORUS
Just gonna float, looking for a substrate
And if I find it then I will accelerate
As long as it's the right shape and size
I'll help it react because I love to catalyze
I love to catalyze

Transition Dialogue
Human: OK I get it. You speed up reactions and you're the reason I am alive. What have you done for me lately?

Enzyme: Really? That's not enough for you? I'll let my buddy restriction enzyme tell you about what he does. Hey, can we go to the bio lab?

"CHOP SOME TAGS"

CHORUS
I'm gonna chop some TAGs
When I recognize that sequence I'ma lop it.
I - I - I'm huntin'. See it - I'ma cut it.
Snip and cut and chop 'em

VERSE
Nah, Roll up to the strand like, "What up, here comes a big chop"
All this DNA just waiting here to be cropped
....I'm bacteria's natural defenda
Cut backbones like an enzyme ninja
Rollin' in, clippin' T's, cleaving 'tween C and G's
Only certain nucs though -- slicin' up specifically
Recognize 4-8 base pairs typically
Blunt ends kinda smooth. But if I cut it jagged-y
It Stiickkksssssssss
All because of those sticky ends (cut it!)
Choppin' it, changin it, askin' "why is this even relevant?"
I'm the key to those biotech tools everybody been sellin' ya.
DNA fingerprintin'? Need an enzyme like me
Solvin' crimes - RFLPs at the crime scene
I'ma cut that gene out, I'ma cut that gene out,
Take it from a jellyfish - put it in a cat - Meow (thank you!)
Can't see the point of a cat with a green glow?
What about bacteria makin insulin though?
Corn needs some carotene? Give that corn some carotene
E. Coli makin that? Now it's making gasoline!
I'm just a - nuc - le-ase makin incisions
You humans are the ones makin' decisions
You can make almost anything that you envision
But think about the consequences 'for I get to snippin'.

B'fore I get to snippin'.
B'fore I get to snippin'.
B'fore I get to snippin'.

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