 In this study, researchers examined the presence of anti-PLA2 antibodies in a group of patients with idiopathic membranous nephropathy, IMN. They found that these antibodies were present in 74% of the patients, but not in those with secondary membranous nephropathy or other forms of primary glomerular diseases. Additionally, they discovered that some patients had high titers of anti-SPLA2 antibodies, which could indicate glomerular structural damage rather than immune system involvement. Overall, their findings suggest that anti-PLA2 are antibodies are specific for IMN, while protonuria may be indicative of both immune system involvement and structural damage. Further studies are needed to explore the potential role of anti-SPLA2 antibodies in IMN. This article was authored by Muhammad Reza Ardalan, Ali Ghaffari, Fateh Mahamzavi, and others.