 It's crazy when you think about all the different kinds of foods we eat. We just swallow and hope it all works out for the best. Well, it turns out there are better ways to think about keeping our bodies humming healthfully along. Welcome to Nutrition Facts. I'm your host, Dr. Michael Greger. Today we've got more from our series on the best diet for thyroid functions, starting with research on plant-based foods and thyroid health. There are several autoimmune diseases that affect the thyroid gland, the most common being Grave's disease and Hashimoto's thyroiditis. Grave's disease results in hyperthyroidism and overactive thyroid gland, though slaughterhouses are supposed to remove thyroid glands. Should some neck meat slip in, you can suffer a similar syndrome called hamburger thyroid toxicosis. But that's not from your body making too much thyroid hormone. That's from your body eating too much thyroid hormone. Grave's disease is much more common, and meat-free diets may be able to help with both, as plant-based diets may be associated with a low prevalence of autoimmune disease in general, as observed, for example, in rural Sub-Saharan Africa. Maybe it's because plants are packed with antioxidants, which are possible protective factors against autoimmune diseases. Maybe it's because plants are packed with anti-inflammatory compounds. After all, a whole-food plant-based diet is basically synonymous with an anti-inflammatory diet, but you don't know until you put it to the test. It turns out the exclusion of all animal foods was associated with half the prevalence of hyperthyroidism compared with omnivorous diets. Lactovovegetarian and fish-only diets were associated with intermediate protection, but a 52% lower odds of hyperthyroidism among those eating strictly plant-based diets. This apparent protection may be due to the exclusion of animal foods, the benefits of plant foods, or both. Animal foods, like meat-eggs and dairy products, may contain high estrogen concentrations, for example, which have been linked to autoimmunity in preclinical studies, or the decrease in animal protein may downregulate IGF1, which is not just a cancer-promoting growth hormone, but may play a role in autoimmune diseases as well, or it could be the good stuff in plants that may protect cells, like the polyphenol phytochemicals, such as flavonoids found in plant foods. Maybe it's the environmental toxins that build up the food chain, for example, that fish contaminated with industrial pollutants like PCBs are associated with increased frequency of thyroid disorders. Okay, what about the other autoimmune thyroid disease Hashimoto's thyroiditis, which, assuming you're good enough iodine, is the primary cause of hypothyroidism in underactive thyroid gland. Grave's disease wasn't the only autoimmune disorder that was rare or virtually unknown among those living in rural Sub-Saharan Africa eating near-vegan diets. They also appeared to have less Hashimoto's. There's evidence that those with Hashimoto's have compromised antioxidant status, but we don't know if it's cause or effect. But if you look at the dietary factors associated with blood levels of autoimmune anti-thyroid antibodies, animal fats seem to be associated with higher levels, whereas vegetables and other plant foods are associated with lower levels. So again, anti-inflammatory diets may be useful. No surprise, this Hashimoto's is an inflammatory disease. That's what thyroiditis means, inflammation of the thyroid gland. Another possibility is the reduction in methionine intake. An amino acid concentrated in animal protein is thought to be one reason why the consumption of whole plant foods is likely to have a favorable influence on longevity through decreasing the risk of cancer, heart disease, and diabetes. Amethionine restriction improves thyroid function in mice, but has yet to be put to the test for Hashimoto's in humans. If you compare the poop of patients with Hashimoto's to controls, the condition appears to be related to a clear reduction in the concentration of prevetella species. Prevetella are good fiber-eating bugs known to enhance anti-inflammatory activities. Decreased prevetella levels are also something you see in other autoimmune conditions, such as multiple sclerosis and type 1 diabetes. How do you get more prevetella? Eat more plants. But put a vegetarian on diet of meat, eggs, and dairy, and within as few as four days you can drive down levels. So one would expect those eating plant-based diets to have less Hashimoto's, but I express concern about insufficient iodine intake, which could also lead to hypothyroidism. So, which is it? Let's find out. Vegan diets tended to be associated with lower, not higher, risk of hypothyroid disease. Why the word tended? Because the associated protection against hypothyroidism incidents and prevalent studies did not reach statistical significance. It wasn't just because they were slimmer, the lower risk existed, even after controlling for body weight. So, they think maybe it's because animal products may induce inflammation. The question I have, though, is if someone who already has Hashimoto's, I mean, what happens if you change their diet? That's exactly what I'll explore next. Finally today, we look at the results of a randomized, double-blind placebo-controlled trial of a half teaspoon of powdered black cumin, a day in Hashimoto's patients. Autoimmune thyroiditis, also known as Hashimoto's disease, is an organ-specific autoimmune disorder, where your body attacks your own thyroid gland, often leading to hypothyroidism, due to destruction and scarring of the gland itself. We know there's a genetic component, since identical twins are more likely to share the disease than fraternal twins. However, even with identical twins, the concordance rate was only about 50%, meaning even if your identical twin with basically the exact same DNA as you has the disease, that's only like a flip of a coin's chance you'll get it, emphasizing that other important factors, other than your genes, play a role in the development of the disease. Genes load the gun, but environment may pull the trigger. More than 90 chemicals have been noted disrupting hormonal balance or thyroid function. However, only a few such pollutants show evidence that they contribute to autoimmune thyroid disease. These include polyaromatic hydrocarbons, which smokers get a lot from their cigarettes. But in non-smokers, exposure comes almost entirely from food. Polycyclic aromatic hydrocarbons are primarily formed when muscle meats, such as beef and pork, fish or chicken, are cooked by high-temperature methods, such as grilling. PBBs are a type of flame retardant chemical, no longer manufactured in the US, but still found in the aquatic food chain. And PCBs are used in a number of industrial processes and end up in people's bodies, largely through the consumption of fish as well, but also other meats and eggs. So one might suspect those eating plant-based diets would have lower rates of hypothyroidism, and indeed, despite their lower iodine and take vegan diets, tended to be protective. But they've never been put to the test in an interventional trial. Modification of the Paleolithic diet has been tried in Hashimoto's patients, but didn't appear to improve thyroid function. What did, though, was Nigella sativa? That name should sound familiar to anyone who's read my latest book, How Not to Diet, or watched my latest live presentation, Evidence-Based Weight Loss. Nigella sativa is the science he named for Black Cumin, which is just a simple spice, but it's also used for a variety of medicinal purposes. In this study, a randomized double-blind placebo-controlled trial of eight weeks of a half teaspoon of powdered black cumin a day in Hashimoto's patients not only was there a significant reduction in body weight, which is why I profiled it in the book, it also significantly reduced thyroid-stimulating hormone, a sign that thyroid function was improving, and even lowered the level of autoimmune anti-thyroid antibodies, as well as increasing blood levels of thyroid hormone T3 in these Hashimoto's patients. In addition, there was a significant drop in interleukin-23, a pro-inflammatory cell signal thought to help promote the autoimmune inflammation of the thyroid, so further confirming the anti-inflammatory nature of the plant. And what were the side effects? 17% drop in LDL-Bad cholesterol. Given the fact that patients with Hashimoto's may be at particularly high risk of developing heart disease, this is exactly the kind of side effect we'd want. Considering these health promoting effects of black cumin, it can be considered as a therapeutic approach in the management of Hashimoto's-related metabolic and abnormalities. A similar trial failed to find a benefit, though, same dose, same timeframe, but no significant changes in thyroid function. In contrast with the last study, though, there were not all Hashimoto's patients who would rather hype both thyroid for any reason, and that may have diluted the results. And it's possible that telling patients to take the black cumin doses with their thyroid hormone replacement therapy may have interfered with its absorption, similar to other foods and drugs, which is why patients are normally told to take it on an empty stomach. Since there are no downsides, and it's just a simple spice, I figure, hey, why not give it a try? And the worst that can happen is you'll have taste of your food. We would love it if you could share with us your stories about reinventing your health through evidence-based nutrition. Go to nutritionfacts.org slash testimonials. We may share it on our social media to help inspire others. To see any graphs, charts, graphics, images, or studies mentioned here, please go to the Nutrition Facts podcast landing page. There you'll find all the detailed information you need, plus links to all the sources we cite for each of these topics. 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