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The Evolving Treatment Paradigm in Myeloma (Part I)

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Uploaded on Sep 16, 2009

Interview with Kenneth C. Anderson, M.D., Dana Farber Cancer Institute / Harvard Medical School.
In this interview by Essinova host BeiBei Song on August 6, 2009 during the IBC Cancer Drug Development Conference in Boston, Dr. Kenneth C. Anderson discusses the effectiveness of combination targeted therapies in the treatment of cancer, as exemplified by multiple myeloma. Phase I-II trials combining two or more novel agents targeting the bone marrow microenvironment, such as Lenalidomide and Bortezomib, have shown significant higher response rates, lower drug resistance and fewer side effects in myeloma patients, according to Dr. Anderson. He also comments on trends shown in the meeting and explains the two ways "combinations" can occur.

Dr. Anderson holds an optimistic view that the next few years will be unprecedented in cancer medicine, because "we now have an understanding of science at the genetic level" to predict and achieve favorable outcome; and if the five core constituencies - pharms, biotechs, academics, regulatory bodies and funding agencies can work together, putting patients first, success will likely come. Acknowledging the challenge of combining drugs from competitors, Dr. Anderson nonetheless asserts that "it is achievable", as has been demonstrated in myeloma's case. He anticipates that "the pressures will be there, not only from the medical sense on behalf of our patients but also from the healthcare system", where outcome is measured in the "New World of Medicine" and that becomes the basis of reimbursement.

Dr. Anderson is the Director of Jerome Lipper Multiple Myeloma Center at the Dana-Farber Cancer Institute, and a Professor of Medicine at Harvard Medical School.

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