 Drug-induced corneal deposits are rare but serious side effect of certain medications. They typically affect the epithelial layer of the cornea, causing opaque spots that can lead to vision loss if left untreated. Some drugs can also cause deposits in the stromal and endothelial layers of the cornea, leading to more severe visual impairments. Treatment options include discontinuing the offending drug, using lubricating eye drops, or applying corticosteroid ointments. This article was authored by Marie-Claude Robert, John Yves Sayoun, and Salma Sabeti.