 Crude glycerol, a byproduct of biodiesel production, presents a challenge due to its potential environmental impacts. However, it can also be used as a source of valuable chemicals and materials through biotechnology. This review summarizes various methods of converting crude glycerol into useful products such as biopolymers, polyunsaturated fatty acids, ethanol, hydrogen, and enbutanol. These products can then be used in a variety of applications, providing additional revenue streams for biodiesel producers. This article was authored by Vijay Kumar Garlapati, Uttara Shankar, and Amrita Bhudraja.