 So there are five scientific work packages within CISACOL IMI and the first work package is work package two which actually focuses on the methodological work that you have to do for using PROs in randomized controlled trials. The next scientific work package that we have is with the single arm studies where they are trying to assess whether it is actually feasible to use PROs in single arm studies and they're developing recommendations for that and we have work package four which focuses on the presentation and the visualization and communication of PRO results for both the randomized controlled trials and the single arm studies and we also have of course work package six which focuses on the interpretation of the results and they talk about they're looking into what does it mean to have a clinically meaningful or clinically relevant change when we in when using PROs and finally we also have work package five which will assess the feasibility of implementing the recommendations that are actually developed by work package two three four and six. So these work packages are very important because they they're actually doing the leg work and they're looking into what are our current practices right now within the PRO field and what are the things that we have to do to actually improve the standards of the PRO field so that we can use the results from PRO data optimally for any kind of decision-making that is being done by the various stakeholders. There's a lot of people involved in these work packages so every work package has different kinds of organizations and they represent various stakeholder groups that are interested in PROs so we usually we have regulators, patient representatives, clinicians, statisticians, PRO experts, HDA bodies and all all the oncological bodies as well and the idea is that we need to put these people together so that we can agree on best practices for PROs in clinical trials. The work packages are actually doing a very difficult job right now because what they're trying to do is gather the thoughts and current thinking of the various stakeholder groups and they're sometimes diverging and so what they need to do is to balance all these thoughts together and come up with recommendations that actually satisfy all the needs of these various stakeholders so recommendations that we can all agree upon so what we are expecting from the work packages are actually a very I would say I would say a lot because we would want them to come up with something that is robust in terms of statistics, feasible and also addresses all the needs of all the various stakeholder groups that we have in physical IMI.