 The SARS-CoV-2 virus has evolved to evade detection and neutralization by the host immune system by modifying its surface glycoprotein, the S-protein. This modification involves changes in the N- and O-glycosylation patterns of the S-protein, which can be seen in the different variants of the virus. These modifications affect the conformational dynamics, receptor interactions, and host immune responses, leading to increased transmissibility and immune evasion.