Elements S3 • E10

A New Pill to Cure Hangovers Is Coming, Here’s How It Works





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Published on Sep 7, 2018

Everyone has their own remedy when it comes to curing hangovers, but soon we may actually have a scientifically-proven one. Here’s how it works so far.

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A hangover pill? Tests on drunk mice show promise
“Inspired by the body’s approach for breaking down alcohol, we chose three natural enzymes that convert alcohol into harmless molecules that are then excreted. That might sound simple, because these enzymes were not new, but the tricky part was to figure out a safe, effective way to deliver them to the liver.”

Alcohol Metabolism: An Update
“Much of the research on alcohol metabolism has focused on an intermediate byproduct that occurs early in the breakdown process—acetaldehyde. Although acetaldehyde is short lived, usually existing in the body only for a brief time before it is further broken down into acetate, it has the potential to cause significant damage.”

A Hepatocyte‐Mimicking Antidote for Alcohol Intoxication
“Inspired by the metabolism of alcohol, a hepatocyte‐mimicking antidote for alcohol intoxication through the codelivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate.”

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