 Hi, I am Dr. Ravichan Siddhachari. I am a consultant hepatobiliary and liver transplant surgeon for Manipal Hospital Group, Bangalore. You need medications to protect the new liver because it's not your own liver. It is transplanted from somebody else. There is always a chance that body may reject. So for this reason you have to take medicines for lifelong to protect the liver. Now when I say you have to take medicines, people think that you have to take a lot of medicines. Actually in the beginning for maybe 3-6 months you will be on lot of medications but over the period of time you will be down to only just one or two medicines. Just like diabetes, hypertension or any chronic disease where you have to take medicines for lifelong. Similarly after liver transplantation after one year you have to take one or two medicines to protect your liver which is actually the cost is not so much after one year. Maybe in the beginning it will be little bit expensive maybe up to 15-20 thousand but after one year it comes down to 5-10 thousand rupees.