 Candida oris is an emerging fungal pathogen that has been identified in Italy since July 2019. It has caused 361 confirmed cases with 146 deaths in 17 healthcare facilities in four Italian regions. Most cases have been found to be colonized rather than infected, suggesting that the fungus may be more widespread than previously thought. The majority of cases have also shown resistance to fluconazole, a commonly used antifungal drug. To date, no cases have been reported outside of Italy. The Italian government has taken steps to contain the outbreak, including weekly screenings of contacts, implementation of IPC measures, and establishment of a national reference laboratory to study the strains. This article was authored by Camilla Sticchi, Roberto Rosso, Lorenza Ferrara, and others.