 The tumor microenvironment, TME, is composed of myeloid immune cells, mics, which are potent innate immune cells that serve as first responders to invading pathogens and internal changes to cellular homeostasis. When these cells detect alterations in the TME, they activate the CGAS Sting Signaling Pathway, which leads to the production of type 1 interferons, IFNs, and other pro-inflammatory cytokines and chemokines. This process is known as TUMA Immune Microenvironment, TME. In this review, we focus on how CGAS Sting Signaling affects the time and how it could be used as a therapeutic target for cancer treatment. This article was authored by Vijay Kumar, Katelyn Bauer, and John H. Stewart.