 This study examined the development, implementation, evaluation and sustainability of continuing professional development, CPD, systems for healthcare professionals in low and lower middle-income countries, LLMICs. It found that leadership and buy-in from key stakeholders, including government bodies and healthcare professional organizations, and a framework essential for the development, implementation and sustainability of a CPD system in a LLMIC. Additionally, it highlighted the importance of a needs assessment, drafting of a policy, which details the regulations, law's norms, the CPD requirements and an approach for monitoring, including an accreditation mechanism, a financing plan, identification and production of appropriate CPD materials and activities, a communication strategy, and an evaluation process. This article was authored by Lisa Mary, Sonja Angela Castiglione, Genevieve Roulou, and others.