 This study examines the barriers and best practices for developing a well-trained clinical research professional, CRP, workforce at academic medical centers. The authors identified several barriers to training the CRP workforce, such as balancing foundational onboarding with role-based training, managing logistical challenges and institutional contexts, identifying in-listing institutional champions, assessing competency, and providing high-quality mentorship. Additionally, two universal threads present throughout all themes are the need for effective communication and the need to improve professionalization of the CRP career pathway. This article was authored by Jacqueline M. Knappke, Michelle Jenkinson, Peg Sal, and others.