 The regenerative ability of skeletal muscle involves coordinated activities of multiple cell types and biomolecular factors, with extracellular matrix being a fundamental component of this process. This review discusses the roles played by muscle satellite cells, other cells, and ECM components in SM myogenesis and regeneration, and examines the effects of their dysregulations on these processes. It also reviews various types of ECM scaffolds and biomaterials used for SM regeneration, recent advances in ECM scaffold research, and their impacts on tissue engineering and SM regeneration, especially in severe muscle injury. The aim is to provide a comprehensive overview of SM myogenesis and regeneration, the stem cells used for muscle regeneration, the significance of ECM in SM regeneration, and to enhance understanding of the essential role of the ECM scaffold during SM regeneration. This article was authored by Kershid Ahmed, Sibgatullah Sheikh, Heejin Chan, and others. We are article.tv, links in the description below.