 Head and neck squamous cell carcinoma, HNCC, is a type of cancer that affects the mouth, throat, nose, and other parts of the head and neck. It is the seventh most common cancer diagnosed worldwide, with approximately 890,000 new cases and 450,000 deaths each year according to global kinestimates. The incidence of HNCC is rising due to increased consumption of tobacco and alcohol, particularly in developing countries. Tobacco and alcohol have a synergistic effect, which can increase the risk of HNCC by up to 40 times. In developed countries, HP-related HNCC is more common than tobacco and alcohol-related disease, and it is associated with a much longer median survival rate of 130 months compared to 20 months. Lifestyle differences, access to health care, and socioeconomic status may also contribute to the higher incidence and worse prognosis of HNCC in certain populations. Pharmacotherapy and counseling have been found to be effective in reducing smoking and alcohol use. This article was authored by Adam Barsuk, John Sukumar Alluru, Prashant Rola, and others. We are article.tv, links in the description below.