 Welcome back to our meds smarter lecture series where we're taking a smarter approach to preparing future physician Before we get started if you'll take just a quick minute and click that like button and also Subscribe and turn the bell on so that you'll be notified when we post new videos Let's talk a little bit about a jarish-herksheimer reaction. What is this reaction? So this is where we see a flu like symptoms associated with the beginning or initiation of antibiotics So what you're gonna see here is patients kind of getting those flu like symptoms often times It's going to be after E. Coli is detected and treated with antibiotics often. We see this instantly first one to three hours and They're gonna see fever chills rigor hypotension headache tachycardia Ventilation vasodilation all these different types of potential flu like symptoms and what's happening here really is this because we're having killed Bacteria like the spirochetes or like E. Coli that are releasing the toxins from their bacteria into the body and It's now causing these reactions This can be life-threatening because they can cause a significant drop in blood pressure because remember I said that hypotension was one of the potential side effects and It can then lead us to an end organ injury So we want to be cautious with that If we do have a jarish-herksheimer reaction associated with antibiotics as you can see in this patient This is gonna be kind of one of those skin rashes associated with a jarish-herksheimer reaction from a patient that was being treated for a gram-negative infection If you found this material helpful for your studying Please like and consider subscribing to the channel also share this video so that more people can benefit from it like you have