 Abstract autophagy is a process by which cells break down and recycle their own components when they are lacking sufficient nutrients or energy. This process is important for maintaining cellular homeostasis and survival. Previous studies have suggested that the AMP-activated protein kinase, AMPK, plays a role in regulating autophagy. In this study, researchers discovered that AMPK actually inhibits autophagy, preventing it from being too strong and potentially damaging the cell. They also found that AMPK can protect the autophagy machinery from destruction during periods of energy deprivation, allowing the cell to continue functioning until the energy crisis has passed. These results suggest that AMPK plays a key role in balancing autophagy levels to ensure proper cellular homeostasis. This article was offered by G-Man Park, D.A. High Lee, and Doohyun Kim.