 Abstract microporous annealed particle scaffolds, maps, are a type of granular material made up of interlinked micro gels. These micro gels can be designed with various mechanical or bioactive properties to facilitate cell infiltration and modulate host response. Changing the chirality of the micro gel cross-linking peptide from L to D amino acids has been shown to lead to significant tissue regeneration and functional recovery in D maps, treated cutaneous wounds. In this study, the immunomodulatory effect of D maps in a subcutaneous implantation model was investigated. Macrophages were found to be the key antigen, presenting cells responsible for uptaking and presenting these biomaterials to the adaptive immune system. A robust linker-specific IgG-2B-slash-IgG-1 response to D maps was detected as early as 14 days post-implantation. This indicates a fine balance between pro-regenerative and pro-inflammatory macrophage phenotypes, suggesting that regenerative scaffolds may have potential applications in tissue engineering. This article was authored by Ening Liu, Alejandra Suarez-Arnado, Shematha Shetty, and others. We are article.tv, links in the description below.