 Multisystem Inflammatory Syndrome in Children, M.I.S.C., also known as Multisystem Inflammatory Syndrome in Adults, M.S.I.A., is a rare and serious complication of COVID-19 that can cause multiple organ dysfunction. Symptoms include fever, abdominal pain, vomiting, diarrhea, skin rashes, red eyes, and swollen lips, tongue, hands and feet. Children typically have negative test results for current infection with the virus, but positive antibody results indicating they had been exposed to the virus in the past. In this case report, we describe a 12-month-old girl who presented with SOGIA and positive COVID-19 PCR. She was treated successfully with dexamethasone and naproxen. This case highlights the importance of considering M.I.S.C. in children with unexplained multi-organ involvement and positive COVID-19 PCR. This article was authored by Nadia Wahid, Niyad Haider, and Jai Krishan. We are article.tv, links in the description below.