 During diet-induced obesity, white adipose tissues experience hypoxia due to adipocyte hypertrophy and dysfunctional vasculature. To adapt to this environment, cells in white adipose tissues activate hypoxia-inducable factor, HIF, transcription factor that activates signaling pathways involved in metabolism, angiogenesis, and survival apoptosis. Exposure to cold or activation of the adrenergic receptor leads to heat generation through uncoupling protein 1, UCP1, in brown adipose tissues. White adipose tissues can also undergo a similar process known as the Browning of White Adipose Tissues or Base Adipocytes. Intact HIF-1 signaling in adipocytes and adipose tissue macrophages exacerbates tissue inflammation and insulin resistance, while up-to-one K-O mice and other models targeting the HIF pathway in endothelial cells have shown beneficial effects on diet induced obesity. This article was authored by G.I.Soukang, Hyjujo, Yirim Lee, and others. We are article.tv, links in the description below.