 How does a vegan or vegetarian diet affect bone density? And what other factors contribute? Watch the video to find out. Osteoporosis is estimated to affect 200 million people worldwide. Literally meaning porous bone, osteoporosis, is a disease characterized by reduced bone formation, excessive bone loss, or combination of both, leading to bone fragility and increased risk of fractures. And bone mineral density is the most robust and consistent predictor of osteoporotic fracture. What can we eat to boost our bone density? Well, we know that increased consumption of plant foods is associated with increased bone mineral density. There's an extensive range of micronutrients and phytochemicals packaged within plants that can be powerful promoters of bone health. So healthcare professionals should be encouraged to advise the increased consumption of plant-based foods, particularly in mid-life, irrespective of the client's underlying dietary pattern, meaning no matter how much meat or junk they eat, adding more healthy plant foods may help prevent the development of osteoporosis. On the other hand, a more animal-sourced nutrient pattern has been associated with a higher risk of fractures, suggesting that a more animal-based diet is related to bone fragility. So we would expect less osteoporosis in those eating plant-based diets, but you don't know until you put it to the test. The incidence of osteoporosis in vegetarians and omnivores is the first study published nearly 50 years ago, and the density of the bones that were measured was significantly greater in the vegetarians than the omnivores. In fact, the average bone density, so the vegetarians in their 70s, was greater than the densities of the meat-eaters in their 50s. Bottom line, these results suggest there's less likelihood of vegetarians developing osteoporosis in the old age. Turns out, though, that the researchers screwed up. Dexascanning, which is what we use now, didn't come online until the 1980s, so the researchers were just using just regular x-rays, and they confused the readings such that darker bones on the x-ray got a higher score, but that actually means less bones, so their conclusion should have been the opposite of what they claimed, so vegetarians had worse bone mineral density. Fast forward about 40 years, by which time nine studies have been done on thousands of individuals, and all in all, the results suggest that vegetarian diets, particularly vegan diets, are associated with lower bone mineral density, but the magnitude of the association is clinically insignificant, meaning the difference was so small as to not really matter out in the real world, reinforcing the fact that vegetarian diets have no clinically detrimental effect on bone health. And it's important to note that the findings of lower bone mineral density didn't fully control for key confounding factors, such as for differences in body weight. We know that people who are obese have stronger bones, why? Because their weight left them 50 pounds all day every day, and maybe 100 pounds. If you walked around with a 100-pound backpack every day, your bones would grow stronger too. That's how you build strong bones, weight-bearing exercise, so people who weigh more have denser bones. And vegetarians, and especially vegans, have such low rates of obesity that no wonder, on average, they would have lower bone density. The researchers didn't take weight into account, but if the difference they found isn't even clinically significant, who cares? As of 2009, the answer to the question, is vegetarianism a serious risk factor for osteoporotic fracture? The answer was, no, vegetarianism is not a serious risk factor. By 2018, the latest meta-analysis on veganism, vegetarianism, and bone mineral density were up to 20 studies involving tens of thousands of participants, and, again, lower bone mineral density was found in studies of vegetarians and vegans compared to meat-eaters. The researchers conclude that vegetarian and vegan diets need to be appropriately planned to preserve their bones. But wait, did they account for the obesity thing? No, they did not. They just used what are called crude risk ratios, meaning no adjustments for confounding factors like weight. So they didn't control for things like age, smoking, obesity, exercise, and so the results are really uninterpretable. But no one had gone through the trouble of going back through all those studies and making the proper adjustments until now. The title gives it away. Differences in bone mineral density between vegetarians and non-vegetarians become marginal when accounting for differences in body size factors. Yes, bone mineral density values were significantly lower among vegetarians than among non-vegetarians, just like is the case with nearly every study on bone mineral density and excess body weight. But forget clinical significance, these differences even lost statistical significance upon adjustment for body size factors, suggesting that lower bone mass among vegetarians is in larger parts explained by their lower BMI and waist circumference. Thus, it's not so much the composition of the diets of vegetarians and vegans as much as it is the fact that they become so much slimmer. Now, a small but statistically significant difference remained for total lower spine density, a difference of 0.03. This was dismissed as having little clinical relevance, but is that true? If you look at the reproducibility of bone mineral density measurements in daily medical practice, you can see how if you repeat test back to back, there's some scatter in the measurements. And so a significant difference really has to be more than the inherent variation, and indeed, expressed as the smallest detected difference, you really need a bone mineral density disparity of at least 0.05 at the spine before it can be considered a significant change. And so indeed, there does appear to be little clinical relevance. However, even if vegetarians and vegans basically have the same bone density at the same weight, everyone who is skinny is at risk. Low BMI is a risk factor for fracture, so all persons in a low body weight category consuming any kind of diet should be monitored for osteoporosis.