 Diabetic foot ulcers are one of the most serious complications of diabetes, often resulting in repeated hospitalizations, infections, gangrene, and ultimately amputations. Mesenchymal stem cells have been shown to promote wound healing by modulating inflammation, stimulating angiogenesis, and differentiating into essential cells at the site of ulcers. This review summarizes the current understanding of how mesenchymal stem cells can help improve the healing process in diabetic foot ulcers. This article was authored by Gonas Mamadvand, Arian Karimi-Ruzbihani, Zara Suttat-Razavi, and others.