 Epigenetics plays a key role in cancer drug resistance by altering the expression of genes involved in cellular processes, such as metabolism, growth, and apoptosis. Histone D-methylases are enzymes that remove methyl groups from histones, which can lead to changes in gene expression and ultimately affect the development of cancer cells. Targeting these enzymes with small molecules or siRNAs may be a promising approach to overcoming drug resistance. This article was authored by Nan Wang, Ting Ma, and Bin Yu.