 congenital vaginal anomalies and pelvic organ prolapse can cause serious physical and emotional distress in women. Surgery and other treatments are available but often come with long-term complications. Tissue-engineered scaffolds offer a promising alternative solution as they mimic the natural environment of the vagina and can be used to reconstruct or repair damaged areas. This article was authored by Saeed Farzam-Far, Alyssa Elia, Megan Richer and others.