 Peaked pseudokinase proteins are involved in controlling cell migration, invasion and proliferation through their ability to recruit key signaling proteins to the cytoskeleton. These proteins lack catalytic activity but have been found to be highly expressed in aggressive cancers. In this study, researchers investigated the molecular mechanisms behind these interactions and identified a conserved 14-3-3 motif on peak 3 which regulates C-RKI binding and signaling via GRB2. This study provides a detailed structural snapshot of peak interaction networks and explains how peak proteins, particularly peak 3, act as dynamic scaffolds to control signal transduction in cell growth and motility. This article was authored by Michael J. Roy, Mingliana G. Surudoi, Ashley Crop, and others.