 The umbrella review synthesized the available evidence on mental health outcomes of quarantine and isolation for preventing infectious diseases, which found severe mental health problems among individuals and populations who have undergone quarantine and isolation in different contexts. This evidence necessitates multi-pronged interventions including policy measures for strengthening mental health services globally and promoting psychosocial well-being among high-risk populations. This article was authored by M. D. Mabab Hossein, Abida Sultana, and Neeta Perot.