 How are wrinkles formed? Their origin and nature is said to be notoriously complex, but current thinking is that wrinkles occur where fault lines develop in aging skin. The process has been compared to an old leather glove, made out of skin after all, that develops creases at the joints due to repetitive stress. In the face, the repeated flexion may be due to facial expression. An eight-year longitudinal study found that you can predict the pattern of persistent wrinkles by superimposing upon your resting face the expression lines, the temporary wrinkles, that form when you smile. Over time, the skin folding caused by everyday facial expressions etches the temporary grooves into permanent wrinkles. See how the smile lines around the eyes at baseline show up as permanent wrinkles eight years later? When wrinkles developed from forehead furrows and expression lines from frowns and laughter, one dermatology journal review on aging skin offered the tongue-in-on-wrinkled cheek suggestion of living alone to minimize the use of facial expressions. And while you're at it, you could live in space to avoid the effects of gravity. However, there is a way to freeze parts of your face into an expressionless mask—botox. In fact, one contraindication to getting botox is having a job that necessitates a wide range of facial expressions. It's never been formally put to the test, but there was a case report of a pair of identical twins, one of whom who spent tens of thousands of dollars getting botox treatments across multiple areas of her face a few times each year for 13 years. Compared to her non-regularly injected twin, she ended up with fewer imprinted facial lines. A paper entitled Sleep Wrinkles tried to make the case that wrinkles may result from the skin distortion from mechanical compression sleeping on your side. Of course, the primary author also was a partner in a company selling $160 quote-unquote wrinkle-fighting pillows. It turns out there does not appear to be any correlation between sleep position preference and the appearance of wrinkles. Speaking of questionable products, what about topical adhesive anti-wrinkle pads you paste to your face at night? Product claims include a look up to 10 to 15 years younger, declaring a 70% reduction in wrinkles, but when actually put to the test for months for crow's feet, forehead, or between-the-eye wrinkles, no objective benefits were reported at all. There did appear to be a placebo effect in that subjectively the study participants felt the wrinkles looked better, but independent blinded evaluations by facial plastic surgeons of before and after pictures showed no significant change. So what can we do to prevent wrinkling? Some of it is genetics. For example, having lighter skin color is a predisposing factor. Among light skin tones, Caucasian skin wrinkles more readily than Asian skin, for which aging is more characterized by pigmentation changes, such as freckles, blotchy patches, and liver spots. Among Asian skin types, Chinese women tend to have more wrinkles around their eyes, and Japanese women, whereas Thai women, tend to wrinkle more in the lower half of their faces. There are, however, factors we have control over. For example, drier skin has also been found predictive of more persistent wrinkling, suggesting regular use of skin moisturizers may help. When it comes to wrinkle formation, it takes two to tango. Wrinkles are formed by repetitive creasing of aged skin. Kids can scrunch their faces all they want, because the architecture of their skin has yet to be irreparably damaged. And the lack of creasing is why you don't have wrinkles on your forearms, no matter how much sun they've soaked up. Rather than immobilizing your face with Botox, you can focus on preventing the underlying structural damage that makes your skin susceptible. This involves tobacco avoidance and regular sun protection. What about safeguarding against other kinds of light? From the Journal of Biomedical Physics and Engineering, can light emitted from smartphone screens and taking selfies cause premature aging in wrinkles? Human skin cells bathed in the light of iPhones and iPads experienced an 80 to 90% increase in free radicals compared to shielded control cells, suggesting electronic device-generated light may be harmful to skin. Now on one hand, they positioned the screens unrealistically close, one centimeter, resulting in about 10 times the irradiance compared to a reading distance of about a foot. On the other hand, the skin cells were only exposed for an unrealistically short time, only an hour. The researchers called for future studies to evaluate the impact of lower, longer doses on skin outcomes, such as with collagen deposition.