 This study aimed to develop a semi-solid vehicle for topical delivery of nano-encapsulated St. John's word extract, rich in hyper-foreign, HP, and explore its wound healing potential. For nanostructured lipid carriers, NLCs were obtained, blank and HP-rich SJW extract loaded, HP NLC. They comprised glycerol-behenate, Gb, as a solid lipid, almond oil, AO, or borage oil, BO, representing the liquid lipid, along with polyoxyethylene-20, sorbitin-maniliate, PSMO, and sorbitin-maniliate, SMO, as surfactants. The dispersions demonstrated an isometric nanoscale particles with acceptable size distribution and disrupted crystalline structure, providing entrapment capacity higher than 70%. The carrier exhibiting preferable characteristics, HP NLC2, was gelled with Palloxymers 407, PM407, to serve as the hydrophilic phase of a Beigel, to which the combination of BO and sorbitin monastere. This article was authored by Joana Sodorova, Vilyana Gugliva, Stanila Stoiva, and others. We are article.tv, links in the description below.