 This paper presents a detailed analysis of the weather, climate, and climate variability in the Andes Cordillera region of South America based on instrumental observations, highlighting the influence of the long meridional extent of the Andes and the disruption of large-scale circulation by this topographic barrier, as well as the impact of the El Nino Southern Oscillation phenomenon on temperature and precipitation regimes in the area. This article was authored by Art D. Garode.