 Hello, I am Ifa Salahuddin, senior scientist responsible for USB Atomax-Setting Hydrochloride monograph. I am going to give you a brief overview on the proposed revision on this monograph which is going to be published in USB PF-474. This proposal is based on the version of the monograph official as of May 1, 2021. In 2010, during the initial release testing of Lot F for Related Compound B, no chiral testing was performed as the monograph did not have a chiral method. The USB monograph for Atomax-Setting Hydrochloride was revised in 2012 to add a new chiral-converting method called Procedure 2. Since then, USB received complaints or feedback from customers who reported that they had difficulty in duplicating the chromatogram for the system's suitability solution containing Atomax-Setting Hydrochloride, its S-i-samer, and the USB Atomax-Setting Related Compound B using Procedure 2. USB launched an internal investigation and confirmed that the USB Atomax-Setting Related Compound B, reference standard, should be replaced with a pure R in endium. The Atomax-Setting Hydrochloride is used to treat attention deficit hyperactivity disorder LDSD, which affects over 6 million children in the US. As per the customer complaints, the current resolution mixture containing the three standards were not well resolved. With the proposed revision to replace the resimate with R-i-samer of the Related Compound B, this issue is expected to be resolved. The system's suitability solution containing USB Atomax-Setting Related Reference Standard, USB Atomax-Setting RCB, reference standard, and USB Atomax-Setting S-i-samer, reference standard were initially tested using Procedure 2, using chiral separation. They showed three distinct peaks and failed to show that the Related Compound B was a resimate. As the new optically pure R in endium of USB Related Compound B, reference standard is approved, here we are proposing to remove the note and chemical information regarding the resmic mixture of RCB from the reference standard section in the monograph and replace it with the single R in endium. Therefore, we'll change the delete the chemical information for the RS in endium, RS resmic mixture and replace it with the R in endium chemical name. Finally, there are other minor wording changes which are made to provide clarity to the users. Please review these revisions and provide your comments using the link provided in the PF website during the public comment period. If you have any questions or concerns, you can reach me at ifr.salahuddin at usp.org. I will respond to your emails in a timely manner. Thank you very much.