 en hier gaan we onze reisarchie-kwescheon. Nu gaan we met een fake lille project op te komen. In andere woorden gaan we geen reale patiëntdata collecten en we gaan het oversymplifie te doen. Het is ongemaakt, het is ongemaakt, die we gaan plukken, just om een basis voor jou te werken. Nu, in meië instances, instituuties, are resource constraint. We doen nie in een fansie, Eerste wereld, Ivery Tower soort situatie, maar dit is eerst het basis van wat nog een soort project kan gebouwen en als we dit doen, kan je nergens doen wat jouw bedekelse research. So, we gaan een sample set van patiënts van een populatie die met die skin- en soft-tissue infectie, door die diebitus militaar. So, die patiënts hebben probleem met the insulin regulation the sugar levels go up in their blood and they are they develop all sorts of infections so we have our make belief little hospital and we admit patients admission criteria's that they must have diabetes and they are admitted because they have some infection either skin or soft tissue infection now we're going to classify these infections into two groups to do that we do have to have a definition we don't have to be rigorous about it yeah i just want to set up two groups to compare to each other and we're just going to call them for argument sake mind infection and major infection we could say that all the mind infections would be someone who's just admitted short term who's just getting some local dressings on their infection on their skin infection getting oral antibiotics and we could say that the definition of major infection would be that they require intravenous antibiotics or some form of surgical intervention cleaning the wound surgically when we do a proper medical research we have to be very proper about these definitions though but for argument sake here we have two groups and we're going to compare various variables between these two groups we've got to define them and what are our questions going to be well we come up with these as clinicians as we do ward rounds as we see patients as i'm a surgeon as i take patients to surgery you start wondering about things you think i wonder if there's a difference there i wonder if i were to do things differently i read something in the literature and that might me might make me think of doing something differently something new thought processes that occur other than just the normal care of the patients so our research question here is really going to be very simple we're going to compare the difference between these two groups that we formed minor infections major infections between these two groups we're going to compare the admission hb a1c and the admission crp so in case you don't know hb a1c is a marker and a patient's blood really tells us how good the blood sugar level control has been in the recent past and crp stands for seriactive protein it's a marker in the blood both of these can be tested in the laboratory by a blood sample it is crp is a marker for infection or inflammation en absolute values are not necessarily that helpful to us as clinicians and clinicians and we really care about the trend so if we do serial analysis and the crp level starts coming down we know we are on top of the inflammation or the infection as it starts rising we are concerned and we might do further investigation even further surgery change our management in some way but the absolute values are not necessarily that crucial but if you have two patients and one and both of them have a crp of 50 they might have very different severity of the infection so it's not the absolute value sure just that we clear about what hb a1c and crp really mean so in the context of this little project here we're just using them as surrogate variables that we can collect data points on and do our analysis so a nice little research project here it's not a real world project we're not collecting any real world examples and the question that i'm asking is is perhaps not not really of any any clinical significance but it's real nice data to work with and we've got our two groups to find we can do our analysis now the next step is going to be to go to the literature and do a search and see what others have published on this topic on these research questions