 This study demonstrated the potential of chytosand modified with a 16-amino acid peptide, CDX, and polyethylene glycol, PEG, to be used as a safe and efficient carrier for gene delivery into the brain. The study found that the CDX-modified chytosand nanoparticles, CSPEG CDX slash PEGFP, were able to enter glioma cells in a dose-dependent manner and could successfully express GFP as a reporter protein in the brain. Additionally, the study showed that the CSPEG CDX slash PEGFP endpiece had minimal side effects such as biodistribution in other organs like the spleen, liver, heart, and kidney. Overall, this study suggests that CSPEG CDX slash PEGFP endpiece are a viable option for gene delivery into the brain. This article was authored by Tina Seppesi, Farhad Bani, Reza Rabarghatsi, and others.