 This study investigated the relationship of three common polymorphisms in the HFE gene C282Y, H63D and S65C with high body iron status in a population of Pakistani patients with type 2 diabetes mellitus, DM, as well as exploring whether any novel mutations exist in the HFE gene in a sample of Pakistani subjects with type 2 DM. The results should know association between these polymorphisms and body iron status in Pakistani subjects with type 2 DM. Additionally, a single base substitution of G nucleotide instead of C at the codon position 187 in the HFE gene Xon2 was discovered in one subject with DM. No association was found between the D allele, variant allele of H63D and type 2 DM. Furthermore, a significant relationship was found between the CG genotype and abnormal albuminuria in subjects with type 2 DM, P equals 0.036. This article was authored by Jibran Swalla Mohamed, Najmal Islam, Naseema Mebubali and others. We are article.tv, links in the description below.