 The extracellular matrix ECM plays a crucial role in maintaining tissue and organ integrity, and it is composed of diverse components that regulate and activate cellular processes. It also influences cell phenotype through its composition, architecture, and elasticity. ECM degradation and remodeling occurs normally, but this process is disrupted in certain pathological conditions, leading to changes in tissue homeostasis. Cellular responses to physical and chemical signals from the ECM are mediated by receptors, including integrants, which drive cellular proliferation and differentiation. Recent advances in the Bohmix technologies have led to increased research into the bidirectional cell matrix interactions, with the aim of understanding how these interactions affect cell behavior and disease progression. Finally, ECM targeted therapies are being developed to target tumor cells and improve cancer treatment outcomes. This article was authored by Kevin Zobo and Khalid Dandara. We are article.tv, links in the description below.