 Medicine today is highly database. Modern medical imaging, pathology, and genetic analysis provide doctors and nurses with extensive information about a patient. Technologies collecting health data become less expensive and more ubiquitous. Hospitals implement digitalization to enable holistic health care in teams of specialists. As the aging society develops more chronic diseases, ever more data is being generated, flooding health care personnel. Much of this data remains unused. Artificial intelligence can help to make this mountain of data usable for timely clinical decisions, creating agile health care systems able to meet these challenges. AI can discover patterns that differentiate between disease types and help choose more precise treatments that will work. It can predict how fast a degenerative disease progresses and suggest the ideal consultation frequency for a patient. It can spot biomarkers and differences in tissues, helping to guide the hand of the surgeon removing a tumor. Here in Bern we have a long tradition in developing medical technology by bringing together physicians and engineers. Our medical innovation takes place within the medical faculty, within the hospital, and all on the campus of the University Hospital of Bern. AI will transform health care in unprecedented ways. The Bern Center for AI and Medicine, short CAME, will actively shape this transformation. CAME brings together players from the health care, science, and industry domains and joins all research on AI and medicine at the University of Bern, Bern University Hospital, the Swiss Institute for Translational and Entrepreneurial Medicine, Ziedem Insel, and the Bern University Psychiatry Services. Tailored programs for medicine and engineering students and further education modules for health care professionals will help transmit the knowledge CAME creates to the next generation. CAME promotes new initiatives, groundbreaking ones at that in the area of clinical and therapeutic approaches in health care. Here at CAME we will promote development and investigation of AI technologies for biosignals, medical robotics, medical imaging, and clinical data science. By allowing access to clinical data and funding for new initiatives that are bottom-up in nature, we will be able to see new projects, new insights all the while, allowing collaboration with industry partners and promoting startups in this ecosystem. At CAME, one of our major goals is that the patients will directly benefit from the technologies that are developed for AI and health care. Together we directly contribute to improve patient care and facilitate daily tasks in health care. We look forward to a world where artificial intelligence ultimately helps patients at the center of care.